Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter?

• Main Authors: Rui-Rui Peng (Author), Juan Wu (Author), Wei Zhao (Author), Tengfei Qi (Author), Mei Shi (Author), Zhifang Guan (Author), Haikong Lu (Author), Fuquan Long (Author), Zixiao Gao (Author), Sufang Zhang (Author), Pingyu Zhou (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Prompt therapy with high-dose intravenous benzylpenicillin for a prolonged period is critical for neurosyphilis patients to avoid irreversible sequelae. However, life-threatening neutropenia has been reported as a complication of prolonged therapy with high doses of benzylpenicillin when...