Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis

• Main Authors: Can Cheng (Author), Hanhui Yao (Author), Heng Li (Author), Jingwen Liu (Author), Zhengyi Liu (Author), Yang Wu (Author), Liang Zhu (Author), Hejie Hu (Author), Zhengdong Fang (Author), Liang Wu (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HMGA2, a pivotal transcription factor, functions as a versatile regulator implicated in the progression of diverse aggressive malignancies. In this study, mass spectrometry was employed to identify ubiquitin-specific proteases that potentially interact with HMGA2, and USP48 was identified as a deubi...