SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation

• Main Authors: Ariane Zutz (Author), Christian Schölz (Author), Stephanie Schneider (Author), Virginia Pierini (Author), Maximilian Münchhoff (Author), Kathrin Sutter (Author), Georg Wittmann (Author), Ulf Dittmer (Author), Rika Draenert (Author), Johannes R. Bogner (Author), Oliver T. Fackler (Author), Oliver T. Keppler (Author)
• Format: Book
• Published: Karger Publishers, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Classical antiviral restriction factors promote cellular immunity by their ability to interfere with virus replication and induction of their expression by proinflammatory cytokines such as interferons. The serine incorporator proteins SERINC3 and SERINC5 potently reduce the infectivity of HIV-1 par...