Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies

• Main Authors: Zorana Ferjancic (Author), Filip Bihelovic (Author), Bojan Vulovic (Author), Radomir Matovic (Author), Milena Trmcic (Author), Aleksandar Jankovic (Author), Milos Pavlovic (Author), Filip Djurkovic (Author), Radivoje Prodanovic (Author), Aleksandra Djurdjevic Djelmas (Author), Nevena Kalicanin (Author), Mario Zlatovic (Author), Dusan Sladic (Author), Thomas Vallet (Author), Marco Vignuzzi (Author), Radomir N. Saicic (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractWe developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase, and mannosidase). Molecular modelling...