Augmentation of Tonic GABAA Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABAA Receptors

• Main Authors: Adam C. Errington (Author), David W. Cope (Author), Vincenzo Crunelli (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2011-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

It is well established that impaired GABAergic inhibition within neuronal networks can lead to hypersynchronous firing patterns that are the typical cellular hallmark of convulsive epileptic seizures. However, recent findings have highlighted that a pathological enhancement of GABAergic signalling w...