Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice

• Main Authors: Alexandra Wallimann (Author), Walker Magrath (Author), Brenna Pugliese (Author), Nino Stocker (Author), Patrick Westermann (Author), Anja Heider (Author), Dominic Gehweiler (Author), Stephan Zeiter (Author), Marcus J. Claesson (Author), R. Geoff Richards (Author), Cezmi A. Akdis (Author), Christopher J. Hernandez (Author), Liam O'Mahony (Author), Keith Thompson (Author), T. Fintan Moriarty (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Short-chain fatty acids (SCFAs) produced by the gut microbiota have previously been demonstrated to play a role in numerous chronic inflammatory diseases and to be key mediators in the gut-bone signaling axis. However, the role of SCFAs in bone fracture healing and its impact on systemic inflammatio...