Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model

• 主要な著者: Teresa R. Taylor-Whiteley (著者), Christine L. Le Maitre (著者), James A. Duce (著者), Caroline F. Dalton (著者), David P. Smith (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2019-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Extensive loss of dopaminergic neurons and aggregation of the protein α-synuclein into ubiquitin-positive Lewy bodies represents a major neuropathological hallmark of Parkinson's disease (PD). At present, the generation of large nuclear-associated Lewy bodies from endogenous wild-type α-synucle...