RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus

• Autori principali: Laura Mandik-Nayak (Autore), James B. DuHadaway (Autore), Jennifer Mulgrew (Autore), Elizabeth Pigott (Autore), Kaylend Manley (Autore), Summer Sedano (Autore), George C. Prendergast (Autore), Lisa D. Laury-Kleintop (Autore)
• Natura: Libro
• Pubblicazione: The Company of Biologists, 2017-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

During the development of autoimmune disease, a switch occurs in the antibody repertoire of B cells so that the production of pathogenic rather than non-pathogenic autoantibodies is enabled. However, there is limited knowledge concerning how this pivotal step occurs. Here, we present genetic and pha...