RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus

• Главные авторы: Laura Mandik-Nayak (Автор), James B. DuHadaway (Автор), Jennifer Mulgrew (Автор), Elizabeth Pigott (Автор), Kaylend Manley (Автор), Summer Sedano (Автор), George C. Prendergast (Автор), Lisa D. Laury-Kleintop (Автор)
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• Опубликовано: The Company of Biologists, 2017-11-01T00:00:00Z.
• Предметы: article
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During the development of autoimmune disease, a switch occurs in the antibody repertoire of B cells so that the production of pathogenic rather than non-pathogenic autoantibodies is enabled. However, there is limited knowledge concerning how this pivotal step occurs. Here, we present genetic and pha...