RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus

• Main Authors: Laura Mandik-Nayak (Author), James B. DuHadaway (Author), Jennifer Mulgrew (Author), Elizabeth Pigott (Author), Kaylend Manley (Author), Summer Sedano (Author), George C. Prendergast (Author), Lisa D. Laury-Kleintop (Author)
• Format: Book
• Published: The Company of Biologists, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During the development of autoimmune disease, a switch occurs in the antibody repertoire of B cells so that the production of pathogenic rather than non-pathogenic autoantibodies is enabled. However, there is limited knowledge concerning how this pivotal step occurs. Here, we present genetic and pha...