Low frequency of the <it>TIRAP </it>S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy

• Main Authors: Oskam Linda (Author), Bienzle Ulrich (Author), Bedu-Addo George (Author), Alpsoy Erkan (Author), Schuring Ron P (Author), Kumpf Oliver (Author), Hamann Lutz (Author), Mockenhaupt Frank P (Author), Schumann Ralf R (Author)
• Format: Book
• Published: BMC, 2009-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The Toll-like receptors (TLRs) mediate innate immunity to various pathogens. A mutation (S180L) in the TLR downstream signal transducer <it>TIRAP </it>has recently been reported to be common in Europeans and Africans and...