Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency

• Main Authors: Juan Carlos Jado (Author), Blanca Humanes (Author), María Ángeles González-Nicolás (Author), Sonia Camaño (Author), José Manuel Lara (Author), Beatriz López (Author), Emilia Cercenado (Author), Julio García-Bordas (Author), Alberto Tejedor (Author), Alberto Lázaro (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gentamicin is a used antibiotic that causes nephrotoxicity in 10-20% of treatment periods, which limits its use considerably. Our results have shown that cilastatin may be a promising therapeutic alternative in toxin-induced acute kidney injury (AKI). Here, we investigated its potential use as a nep...