Nephroprotective Effect of Cilastatin against Gentamicin-Induced Renal Injury In Vitro and In Vivo without Altering Its Bactericidal Efficiency

• Główni autorzy: Juan Carlos Jado (Autor), Blanca Humanes (Autor), María Ángeles González-Nicolás (Autor), Sonia Camaño (Autor), José Manuel Lara (Autor), Beatriz López (Autor), Emilia Cercenado (Autor), Julio García-Bordas (Autor), Alberto Tejedor (Autor), Alberto Lázaro (Autor)
• Format: Książka
• Wydane: MDPI AG, 2020-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Gentamicin is a used antibiotic that causes nephrotoxicity in 10-20% of treatment periods, which limits its use considerably. Our results have shown that cilastatin may be a promising therapeutic alternative in toxin-induced acute kidney injury (AKI). Here, we investigated its potential use as a nep...