A Semi-Mechanistic Population Pharmacokinetic Model of Noscapine in Healthy Subjects Considering Hepatic First-Pass Extraction and CYP2C9 Genotypes

• Main Authors: Zhendong Chen (Author), Max Taubert (Author), Chunli Chen (Author), Jana Boland (Author), Qian Dong (Author), Muhammad Bilal (Author), Charalambos Dokos (Author), Bertil Wachall (Author), Manfred Wargenau (Author), Bernhard Scheidel (Author), Martin H. J. Wiesen (Author), Elke Schaeffeler (Author), Roman Tremmel (Author), Matthias Schwab (Author), Uwe Fuhr (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Introduction Noscapine is a commonly used cough suppressant, with ongoing research on its anti-inflammatory and anti-tumor properties. The drug has a pronounced pharmacokinetic variability. Objective This evaluation aims to describe the pharmacokinetics of noscapine using a semi-mechanistic...