Targeting 7KCh-Induced Cell Death Response Mediated by p38, P2X7 and GSDME in Retinal Pigment Epithelium Cells with Sterculic Acid

• Egile Nagusiak: Ana Pariente (Egilea), Rafael Peláez (Egilea), Rodrigo Ochoa (Egilea), Álvaro Pérez-Sala (Egilea), Ángela Villanueva-Martínez (Egilea), Miriam Bobadilla (Egilea), Ignacio M. Larráyoz (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Age-related macular degeneration (AMD) is the main cause of blindness in developed countries. AMD is characterized by the formation of drusen, which are lipidic deposits, between retinal pigment epithelium (RPE) and the choroid. One of the main molecules accumulated in drusen is 7-Ketocholesterol (7...