Intracellular and Plasma Trough Concentration and Pharmacogenetics of Telaprevir

• Main Authors: Jessica Cusato (Author), Sarah Allegra (Author), Amedeo De Nicolò (Author), Lucio Boglione (Author), Giovanna Fatiguso (Author), Adnan Mohamed Abdi (Author), Giuseppe Cariti (Author), Giovanni Di Perri (Author), Antonio D'Avolio (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: Triple therapy for HCV-1 infection consists in boceprevir or telaprevir, ribavirin and PEG-interferon. Telaprevir is a P-glycoprotein substrate and it is metabolized by CYP3A4/5. No data have been published on intracellular penetration of telaprevir. We determined peripheral blood mononucle...