Development of [²²⁵Ac]Ac-PSMA-I&T for Targeted Alpha Therapy According to GMP Guidelines for Treatment of mCRPC

• Main Authors: Eline L. Hooijman (Author), Yozlem Chalashkan (Author), Sui Wai Ling (Author), Figen F. Kahyargil (Author), Marcel Segbers (Author), Frank Bruchertseifer (Author), Alfred Morgenstern (Author), Yann Seimbille (Author), Stijn L. W. Koolen (Author), Tessa Brabander (Author), Erik de Blois (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recently, promising results of the antitumor effects were observed in patients with metastatic castration-resistant prostate cancer treated with ¹⁷⁷Lu-labeled PSMA-ligands. Radionuclide therapy efficacy may even be improved by using the alpha emitter Ac-225. Higher efficacy is...