Geniposide Possesses the Protective Effect on Myocardial Injury by Inhibiting Oxidative Stress and Ferroptosis via Activation of the Grsf1/GPx4 Axis

• Main Authors: Yuehong Shen (Author), Xindong Wang (Author), Xinyu Shen (Author), Yue Wang (Author), Shulin Wang (Author), Yunyun Zhang (Author), Xiaoming Yao (Author), Yijiao Xu (Author), Ming Sang (Author), Jiamin Pan (Author), Yu Qin (Author), Qian Zhou (Author), Jianping Shen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reactive oxygen species (ROS) produced in the ischemic myocardium can induce cardiomyocyte injury and death, resulting in cardiac remodeling. Ferroptosis, known as a newly type of cell death caused by iron-dependent oxidative stress, which is an essential death mechanism in cardiomyocytes. However,...