NCSTN Gene Silencing Inhibits the Retinoic Acid Signaling Pathway in Human Immortalized Keratinocytes

• Main Authors: Ying-Da Wu (Author), Qiu-Xia Mao (Author), Yuan-Yuan Zhang (Author), Ping Cheng (Author), Wen-Rui Li (Author), Yan-Yan He (Author), Hao-Xiang Xu (Author), Bao-Xi Wang (Author), Cheng-Rang Li (Author)
• Format: Book
• Published: Wolters Kluwer Health, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract. Objective:. Acne inversa is a multifactorial chronic debilitating disease. Genetic factors are involved in 40% of patients, especially the nicastrin (NCSTN) gene. However, the role of the mutated NCSTN gene in the pathogenesis of acne inversa remains unclear. Retinoic acid is recommends to...