Diacerein, its beneficial impact on chondrocytes and notable new clinical applications

• Main Authors: Daljit Kaur (Author), Jaspreet Kaur (Author), Sukhmeet Singh Kamal (Author)
• Formato: Livro
• Publicado em: Universidade de São Paulo, 2019-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Diacerein (DCN) was obtained by diacetylation of an anthraquinone derivative rhein and was approved by FDA in 2008, in the treatment of osteoarthritis due to its inhibitory effect on proinflammatory cytokines, including IL-6 and IL-1β. It was synthesized in 1980s and marketed as a tablet in some Eur...