Pain Modulation in WAG/Rij Epileptic Rats (A Genetic Model of Absence Epilepsy): Effects of Biological and Pharmacological Histone Deacetylase Inhibitors

• Main Authors: Carmen De Caro (Author), Lorenzo Di Cesare Mannelli (Author), Jacopo Junio Valerio Branca (Author), Laura Micheli (Author), Rita Citraro (Author), Emilio Russo (Author), Giovambattista De Sarro (Author), Carla Ghelardini (Author), Antonio Calignano (Author), Roberto Russo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epigenetic mechanisms are involved in epilepsy and chronic pain development. About that, we studied the effects of the natural histone deacetylase (HDAC) inhibitor sodium butyrate (BUT) in comparison with valproic acid (VPA) in a validated genetic model of generalized absence epilepsy and epileptoge...