The Dipeptide Monoester Prodrugs of Floxuridine and Gemcitabine-Feasibility of Orally Administrable Nucleoside Analogs
Dipeptide monoester prodrugs of floxuridine and gemcitabine were synthesized. Their chemical stability in buffers, enzymatic stability in cell homogenates, permeability in mouse intestinal membrane along with drug concentration in mouse plasma, and anti-proliferative activity in cancer cells were de...
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MDPI AG,
2014-01-01T00:00:00Z.
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