The Effects of Acute and Chronic Selective Phosphodiesterase 1 Inhibition on Smooth Muscle Cell-Associated Aging Features

• Main Authors: Keivan Golshiri (Author), Ehsan Ataei Ataabadi (Author), Annika A. Jüttner (Author), Gretchen L. Snyder (Author), Robert E Davis (Author), Amy Lin (Author), Lei Zhang (Author), René de Vries (Author), Ingrid M Garrelds (Author), Frank P. J. Leijten (Author), A. H. Jan Danser (Author), Anton J. M. Roks (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Age-related cardiovascular diseases (CVDs) remain among the leading global causes of death, and vascular smooth muscle cell (VSMC) remodeling plays an essential role in its pathology. Reduced NO-cGMP pathway signaling is a major feature and pathogenic mechanism underlying vasodilator dysfunction. Re...