The impact of tumour pH on cancer progression: strategies for clinical intervention

• Main Authors: Carol Ward (Author), James Meehan (Author), Mark E Gray (Author), Alan F Murray (Author), David J Argyle (Author), Ian H Kunkler (Author), Simon P Langdon (Author)
• Format: Bog
• Udgivet: Open Exploration Publishing Inc., 2020-04-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the contro...