Population pharmacokinetic study in children with vascular anomalies: body weight as a key variable in predicting the initial dose and dosing frequency of sirolimus

• Main Authors: Lin Fan (Author), Hong-Li Guo (Author), Yue-Tao Zhao (Author), Yue Li (Author), Wei-Jun Wang (Author), Jian Huang (Author), Ya-Hui Hu (Author), Ji-Jun Zou (Author), Feng Chen (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BackgroundThe main challenges faced when using sirolimus in children with vascular anomalies (VAs) still include significant pharmacokinetic (PK) variability, uncertainty in the target concentration range, as well as inconsistencies in initial dosing and dosing frequency. The aim of this study is to...