Selective Modification of Streptozotocin at the C3 Position to Improve Its Bioactivity as Antibiotic and Reduce Its Cytotoxicity towards Insulin-Producing β Cells

With the increasing resistance of bacteria to current antibiotics, novel compounds are urgently needed to treat bacterial infections. Streptozotocin (STZ) is a natural product that has broad-spectrum antibiotic activity, albeit with limited use because of its toxicity to pancreatic β cells. In an at...

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Bibliographic Details
Main Authors: Ji Zhang (Author), Liubov Yakovlieva (Author), Bart J. de Haan (Author), Paul de Vos (Author), Adriaan J. Minnaard (Author), Martin D. Witte (Author), Marthe T. C. Walvoort (Author)
Format: Book
Published: MDPI AG, 2020-04-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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