Selective Modification of Streptozotocin at the C3 Position to Improve Its Bioactivity as Antibiotic and Reduce Its Cytotoxicity towards Insulin-Producing β Cells

• Auteurs principaux: Ji Zhang (Auteur), Liubov Yakovlieva (Auteur), Bart J. de Haan (Auteur), Paul de Vos (Auteur), Adriaan J. Minnaard (Auteur), Martin D. Witte (Auteur), Marthe T. C. Walvoort (Auteur)
• Format: Livre
• Publié: MDPI AG, 2020-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

With the increasing resistance of bacteria to current antibiotics, novel compounds are urgently needed to treat bacterial infections. Streptozotocin (STZ) is a natural product that has broad-spectrum antibiotic activity, albeit with limited use because of its toxicity to pancreatic β cells. In an at...