Selective Modification of Streptozotocin at the C3 Position to Improve Its Bioactivity as Antibiotic and Reduce Its Cytotoxicity towards Insulin-Producing β Cells

• Những tác giả chính: Ji Zhang (Tác giả), Liubov Yakovlieva (Tác giả), Bart J. de Haan (Tác giả), Paul de Vos (Tác giả), Adriaan J. Minnaard (Tác giả), Martin D. Witte (Tác giả), Marthe T. C. Walvoort (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2020-04-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

With the increasing resistance of bacteria to current antibiotics, novel compounds are urgently needed to treat bacterial infections. Streptozotocin (STZ) is a natural product that has broad-spectrum antibiotic activity, albeit with limited use because of its toxicity to pancreatic β cells. In an at...