Encapsulated Cells Expressing a Chemotherapeutic Activating Enzyme Allow the Targeting of Subtoxic Chemotherapy and Are Safe and Efficacious: Data from Two Clinical Trials in Pancreatic Cancer

• Main Authors: J. Matthias Löhr (Author), Stephan L. Haas (Author), Jens C. Kröger (Author), Helmut M. Friess (Author), Raimund Höft (Author), Peter E. Goretzki (Author), Christian Peschel (Author), Markus Schweigert (Author), Brian Salmons (Author), Walter H. Gunzburg (Author)
• Format: Book
• Published: MDPI AG, 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite progress in the treatment of pancreatic cancer, there is still a need for improved therapies. In this manuscript, we report clinical experience with a new therapy for the treatment of pancreatic cancer involving the implantation of encapsulated cells over-expressing a cytochrome P450 enzyme...