Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

• Main Authors: Yukiko Miyazaki (Author), Daniel K. Inaoka (Author), Tomoo Shiba (Author), Hiroyuki Saimoto (Author), Takaya Sakura (Author), Eri Amalia (Author), Yasutoshi Kido (Author), Chika Sakai (Author), Mari Nakamura (Author), Anthony L. Moore (Author), Shigeharu Harada (Author), Kiyoshi Kita (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool. We have discovered ascofuranone (1), a natural compound p...