Gene Therapy for Neuropathic Pain through siRNA-IRF5 Gene Delivery with Homing Peptides to Microglia

• Autors principals: Tomoya Terashima (Autor), Nobuhiro Ogawa (Autor), Yuki Nakae (Autor), Toshiyuki Sato (Autor), Miwako Katagi (Autor), Junko Okano (Autor), Hiroshi Maegawa (Autor), Hideto Kojima (Autor)
• Format: Llibre
• Publicat: Elsevier, 2018-06-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Astrocyte- and microglia-targeting peptides were identified and isolated using phage display technology. A series of procedures, including three cycles of both in vivo and in vitro biopanning, was performed separately in astrocytes and in M1 or M2 microglia, yielding 50-58 phage plaques in each cell...