Neutrophil extracellular traps contribute to the pathogenesis of leprosy type 2 reactions.

• Main Authors: Camila Oliveira da Silva (Author), André Alves Dias (Author), José Augusto da Costa Nery (Author), Alice de Miranda Machado (Author), Helen Ferreira (Author), Thais Fernanda Rodrigues (Author), João Pedro Sousa Santos (Author), Natalia Rocha Nadaes (Author), Euzenir Nunes Sarno (Author), Elvira Maria Saraiva (Author), Verônica Schmitz (Author), Maria Cristina Vidal Pessolani (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Up to 50% of patients with the multibacillary form of leprosy are expected to develop acute systemic inflammatory episodes known as type 2 reactions (T2R), thus aggravating their clinical status. Thalidomide rapidly improves T2R symptoms. But, due to its restricted use worldwide, novel alternative t...