Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism

• Main Authors: Haihua Shang (Author), Ze Wang (Author), Hong Ma (Author), Yinghui Sun (Author), Xiaoyan Ci (Author), Yuan Gu (Author), Changxiao Liu (Author), Duanyun Si (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Rotundic acid (RA), a plant-derived pentacyclic triterpene acid, has been reported to possess extensive pharmacological activities. The poor bioavailability limits its further development and potential clinic application. Objective To clarify the potential mechanism for poor oral bioavailabi...