Targeting extracellular nutrient dependencies of cancer cells

• Main Authors: Javier Garcia-Bermudez (Author), Robert T. Williams (Author), Rohiverth Guarecuco (Author), Kıvanç Birsoy (Author)
• Format: Knjiga
• Izdano: Elsevier, 2020-03-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Background: Cancer cells rewire their metabolism to meet the energetic and biosynthetic demands of their high proliferation rates and environment. Metabolic reprogramming of cancer cells may result in strong dependencies on nutrients that could be exploited for therapy. While these dependencies may...