Diethyldithiocarbamate-ferrous oxide nanoparticles inhibit human and mouse glioblastoma stemness: aldehyde dehydrogenase 1A1 suppression and ferroptosis induction

• Auteurs principaux: Marwa M. Abu-Serie (Auteur), Satoru Osuka (Auteur), Lamiaa A. Heikal (Auteur), Mohamed Teleb (Auteur), Assem Barakat (Auteur), Vikas Dudeja (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The development of effective therapy for eradicating glioblastoma stem cells remains a major challenge due to their aggressive growth, chemoresistance and radioresistance which are mainly conferred by aldehyde dehydrogenase (ALDH)1A1. The latter is the main stemness mediator via enhancing signaling...