A simple HPLC method for the determination of halcinonide in lipid nanoparticles: development, validation, encapsulation efficiency, and in vitro drug permeation

• Main Authors: Clarissa Elize Lopes (Author), Gisele Langoski (Author), Traudi Klein (Author), Priscileila Colerato Ferrari (Author), Paulo Vitor Farago (Author)
• Format: Book
• Published: Universidade de São Paulo, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT Halcinonide is a high-potency topical glucocorticoid used for skin inflammation treatments that presents toxic systemic effects. A simple and quick analytical method to quantify the amount of halcinonide encapsulated into lipid nanoparticles, such as polymeric lipid-core nanoparticles and s...