A simple HPLC method for the determination of halcinonide in lipid nanoparticles: development, validation, encapsulation efficiency, and in vitro drug permeation

• Hauptverfasser: Clarissa Elize Lopes (Verfasst von), Gisele Langoski (Verfasst von), Traudi Klein (Verfasst von), Priscileila Colerato Ferrari (Verfasst von), Paulo Vitor Farago (Verfasst von)
• Format: Buch
• Veröffentlicht: Universidade de São Paulo, 2017-06-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

ABSTRACT Halcinonide is a high-potency topical glucocorticoid used for skin inflammation treatments that presents toxic systemic effects. A simple and quick analytical method to quantify the amount of halcinonide encapsulated into lipid nanoparticles, such as polymeric lipid-core nanoparticles and s...