The design and virtual screening of thiourea derivatives as a Sirtuin-1 inhibitor

• Main Authors: Ruswanto Ruswanto (Author), Richa Mardianingrum (Author), Ade Dwi Septian (Author), Arry Yanuar (Author)
• 格式: 图书
• 出版: Pensoft Publishers, 2023-11-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

The SIRT1 is overexpressed in a number of cancers. As a result, inhibiting SIRT1 may be used as a cancer treatment technique. Modification of 1-benzoyl-3-methylthiourea derivatives was carried out in this study by changing the aromatic side. The designed compounds (94) were subjected to in silico do...