Design and Synthesis of Novel <i>N</i>-Benzylidene Derivatives of 3-Amino-4-imino-3,5-dihydro-4<i>H</i>-chromeno[2,3-<i>d</i>]pyrimidine under Microwave, <i>In Silico</i> ADME Predictions, <i>In Vitro</i> Antitumoral Activities and <i>In Vivo</i> Toxicity

• Main Authors: Sirine Karoui (Author), Marwa Dhiabi (Author), Mehdi Fakhfakh (Author), Souhir Abid (Author), Emmanuelle Limanton (Author), Rémy Le Guével (Author), Thierry D. Charlier (Author), Anthony Mainguy (Author), Olivier Mignen (Author), Ludovic Paquin (Author), Houcine Ammar (Author), Jean-Pierre Bazureau (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synthesis of a series of new <i>N</i>-benzylidene derivatives of 3-amino-4-imino-3,5-dihydro-4<i>H</i>-chromeno[2,3-<i>d</i>]pyrimidine <b>10(a-l)</b> bearing two points of molecular diversity is reported. These new compounds were synthesized in fi...