Hyperlipidemia Increases Nalbuphine Brain Accumulation with Multiple Dosing without Affecting Its Analgesic Response-Its Respiratory Depression Potential Should Be Investigated in Future Studies

• Main Authors: Marwa E. Elsherbiny (Author), May Almukainzi (Author), Eman Amer (Author), Marwan Emara (Author)
• Formato: Libro
• Publicado: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Nalbuphine is associated with a significant risk of respiratory depression. Its central nervous system entry is hindered by P-glycoproteins, and lower P-glycoprotein activity is a risk factor for respiratory depression. We assessed the effect of hyperlipidemia on nalbuphine pharmacokinetics, brain a...