Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble Δ9-THC and Morphine Effects: Reversal by Cannabinoid CB1 Receptor Antagonism

• Main Authors: Ismail Nurul Iman (Author), Nur Aimi Zawami Ahmad (Author), Nurul Aiman Mohd Yusof (Author), Ummi Nasrah Talib (Author), Anwar Norazit (Author), Jaya Kumar (Author), Muhammad Zulfadli Mehat (Author), Zurina Hassan (Author), Christian P. Müller (Author), Mustapha Muzaimi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Kratom is a widely abused plant-based drug preparation with a global interest in recent years, well beyond its native grounds in Southeast Asia. Mitragynine, its major psychoactive constituent is known to exhibit opioid-like behavioral effects with resultant neuroplasticity in the brain reward syste...