Arf6 as a therapeutic target: Structure, mechanism, and inhibitors

• Главные авторы: Dejuan Sun (Автор), Yuanyuan Guo (Автор), Piyu Tang (Автор), Hua Li (Автор), Lixia Chen (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2023-10-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

ADP-ribosylation factor 6 (Arf6), a small G-protein of the Ras superfamily, plays pivotal roles in multiple cellular events, including exocytosis, endocytosis, actin remodeling, plasma membrane reorganization and vesicular transport. Arf6 regulates the progression of cancer through the activation of...