Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.

• Main Authors: Diego Benítez (Author), Andrea Medeiros (Author), Lucía Fiestas (Author), Esteban A Panozzo-Zenere (Author), Franziska Maiwald (Author), Kyriakos C Prousis (Author), Marina Roussaki (Author), Theodora Calogeropoulou (Author), Anastasia Detsi (Author), Timo Jaeger (Author), Jonas Šarlauskas (Author), Lucíja Peterlin Mašič (Author), Conrad Kunick (Author), Guillermo R Labadie (Author), Leopold Flohé (Author), Marcelo A Comini (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione,...