Modeling the protein binding non-linearity in population pharmacokinetic model of valproic acid in children with epilepsy: a systematic evaluation study

Background: Several studies have investigated the population pharmacokinetics (popPK) of valproic acid (VPA) in children with epilepsy. However, the predictive performance of these models in the extrapolation to other clinical environments has not been studied. Hence, this study evaluated the predic...

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Main Authors: Lina Zhang (Author), Maochang Liu (Author), Weiwei Qin (Author), Dandan Shi (Author), Junjun Mao (Author), Zeyun Li (Author)
Format: Book
Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
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3rd Floor Main Library

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