The Manufacture of GMP-Grade Bone Marrow Stromal Cells with Validated In Vivo Bone-Forming Potential in an Orthopedic Clinical Center in Brazil

• Main Authors: Rhayra B. Dias (Author), João A. M. Guimarães (Author), Marco B. Cury (Author), Leonardo R. Rocha (Author), Elaine S. da Costa (Author), Liebert P. Nogueira (Author), Camila Hochman-Mendez (Author), Anneliese Fortuna-Costa (Author), Anna Karoline F. Silva (Author), Karin S. Cunha (Author), Sergio A. L. de Souza (Author), Maria Eugênia L. Duarte (Author), Rafaela C. Sartore (Author), Danielle C. Bonfim (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In vitro-expanded bone marrow stromal cells (BMSCs) have long been proposed for the treatment of complex bone-related injuries because of their inherent potential to differentiate into multiple skeletal cell types, modulate inflammatory responses, and support angiogenesis. Although a wide variety of...