A rapid and sensitive High-Performance Liquid Chromatography method with fluorescence detection for quantification of melatonin in small volume rat plasma samples: application to a preclinical study to determine the oral pharmacokinetics of melatonin under gestational conditions

• Główni autorzy: Alberto Gutiérrez López (Autor), Ivan Pantic (Autor), Héctor Flores Herrera (Autor), José Carlos Aguilar Carrasco (Autor)
• Format: Książka
• Wydane: Universidade de São Paulo, 2024-02-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract A novel, simple and sensitive high-performance liquid chromatography with fluorescence detection method was developed and validated for the characterization of the preclinical pharmacokinetics of melatonin under pregnant conditions. Plasma samples (25 µL) were treated with 30 µL of ethanol...