Mangiferin Improves Hepatic Lipid Metabolism Mainly Through Its Metabolite-Norathyriol by Modulating SIRT-1/AMPK/SREBP-1c Signaling

• Hlavní autoři: Jian Li (Autor), Mengyang Liu (Autor), Haiyang Yu (Autor), Wei Wang (Autor), Lifeng Han (Autor), Qian Chen (Autor), Jingya Ruan (Autor), Shaoshi Wen (Autor), Yi Zhang (Autor), Tao Wang (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Objective: Mangiferin (MGF) is a natural xanthone, with regulation effect on lipid metabolism. However, the molecular mechanism remains unclear. We purposed after oral administration, MGF is converted to its active metabolite(s), which contributes to the effects on lipid metabolism.Methods: KK-Ay mi...