HT-SELEX-based identification of binding pre-miRNA hairpin-motif for small molecules

• Autori principali: Sanjukta Mukherjee (Autore), Asako Murata (Autore), Ryoga Ishida (Autore), Ayako Sugai (Autore), Chikara Dohno (Autore), Michiaki Hamada (Autore), Sudhir Krishna (Autore), Kazuhiko Nakatani (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2022-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Selective targeting of biologically relevant RNAs with small molecules is a long-standing challenge due to the lack of clear understanding of the binding RNA motifs for small molecules. The standard SELEX procedure allows the identification of specific RNA binders (aptamers) for the target of intere...