SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides

• Main Authors: Bianca Pierattini (Author), Sabrina D'Agostino (Author), Carlotta Bon (Author), Omar Peruzzo (Author), Andrej Alendar (Author), Azzurra Codino (Author), Gloria Ros (Author), Francesca Persichetti (Author), Remo Sanges (Author), Piero Carninci (Author), Claudio Santoro (Author), Stefano Espinoza (Author), Paola Valentini (Author), Luca Pandolfini (Author), Stefano Gustincich (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SINEUPs are natural and synthetic antisense long non-coding RNAs (lncRNAs) selectively enhancing target mRNAs translation by increasing their association with polysomes. This activity requires two RNA domains: an embedded inverted SINEB2 element acting as effector domain, and an antisense region, th...