Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs

• मुख्य लेखकों: David Damoiseaux (लेखक), Wenlong Li (लेखक), Alejandra Martínez-Chávez (लेखक), Jos H. Beijnen (लेखक), Alfred H. Schinkel (लेखक), Alwin D. R. Huitema (लेखक), Thomas P. C. Dorlo (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The extrapolation of drug exposure between species remains a challenging step in drug development, contributing to the low success rate of drug approval. As a consequence, extrapolation of toxicology from animal models to humans to evaluate safe, first-in-human (FIH) doses requires high safety margi...