Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells

• প্রধান লেখক: Yan Zhang (লেখক), Qin Wang (লেখক), Luolan Li (লেখক), Yi Le (লেখক), Li Liu (লেখক), Jing Yang (লেখক), Yongliang Li (লেখক), Guochen Bao (লেখক), Longjia Yan (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects against wild type epidermal growth factor receptor tyros...