Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation

• मुख्य लेखकों: Tatiana Takiishi (लेखक), Peng Xiao (लेखक), Marie Franchimont (लेखक), Eduardo H. Gilglioni (लेखक), Erick N. Arroba (लेखक), Esteban N. Gurzov (लेखक), Mathieu JM. Bertrand (लेखक), Alessandra K. Cardozo (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objectives: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of β-cell loss in T1D. The receptor interacting serine/t...