Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation

• Main Authors: Tatiana Takiishi (Author), Peng Xiao (Author), Marie Franchimont (Author), Eduardo H. Gilglioni (Author), Erick N. Arroba (Author), Esteban N. Gurzov (Author), Mathieu JM. Bertrand (Author), Alessandra K. Cardozo (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Type 1 diabetes (T1D) is caused by progressive immune-mediated loss of insulin-producing β-cells. Inflammation is detrimental to β-cell function and survival, moreover, both apoptosis and necrosis have been implicated as mechanisms of β-cell loss in T1D. The receptor interacting serine/t...