Dihydronaphthalenone chalconoid derivatives as potential cathepsin B inhibitors; design, synthesis, cytotoxicity evaluation and docking analysis

• Главные авторы: Sara Ranjbar (Автор), Mohammad Reza Shabanpoor (Автор), Zahra Dehghani (Автор), Omidreza Firuzi (Автор), Najmeh Edraki (Автор), Mehdi Khoshneviszadeh (Автор)
• Формат: ‌
• Опубликовано: Universidade de São Paulo, 2021-09-01T00:00:00Z.
• Предметы: article
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Cathepsin B, an abundant expressed cysteine peptidase, plays a key role in cancer cell proliferation, tumor metastasis, apoptosis, angiogenesis, invasion and migration. Therefore, development of cathepsin B inhibitors to treat cancer is of great significance. In this study, dihydronaphthalenone chal...