Dihydronaphthalenone chalconoid derivatives as potential cathepsin B inhibitors; design, synthesis, cytotoxicity evaluation and docking analysis

Cathepsin B, an abundant expressed cysteine peptidase, plays a key role in cancer cell proliferation, tumor metastasis, apoptosis, angiogenesis, invasion and migration. Therefore, development of cathepsin B inhibitors to treat cancer is of great significance. In this study, dihydronaphthalenone chal...

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Main Authors: Sara Ranjbar (Author), Mohammad Reza Shabanpoor (Author), Zahra Dehghani (Author), Omidreza Firuzi (Author), Najmeh Edraki (Author), Mehdi Khoshneviszadeh (Author)
Format: Book
Published: Universidade de São Paulo, 2021-09-01T00:00:00Z.
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