Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin

• Main Authors: Wouter Vankrunkelsven (Author), Sarah Derde (Author), Jan Gunst (Author), Sarah Vander Perre (Author), Emiel Declerck (Author), Lies Pauwels (Author), Inge Derese (Author), Greet Van den Berghe (Author), Lies Langouche (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Muscle weakness is a frequently occurring complication of sepsis, associated with increased morbidity and mortality. Interestingly, obesity attenuates sepsis‐induced muscle wasting and weakness. As the adipokine leptin is strongly elevated in obesity and has been shown to affect...