Thiram, an inhibitor of 11ß-hydroxysteroid dehydrogenase type 2, enhances the inhibitory effects of hydrocortisone in the treatment of osteosarcoma through Wnt/β-catenin pathway

• Autori principali: You Zhang (Autore), Nanjing Li (Autore), He Li (Autore), Maojia Chen (Autore), Wei Jiang (Autore), Wenhao Guo (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2023-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background The anti-osteosarcoma effects of hydrocortisone and thiram, an inhibitor of type 2 11ß-hydroxysteroid dehydrogenase (11HSD2), have not been reported. The purpose of this study was to investigate the effects of hydrocortisone alone or the combination of hydrocortisone with thiram...